Article
Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.
Oncogene - 17 Apr 2003
Lee Gang-Hong, Nishimori Hiroyuki, Sasaki Yasushi, Matsushita Hiroshi, Kitagawa Tomoyuki, Tokino Takashi
Abstract excerpt
The Pulmonary adenoma resistance 2 (Par2) locus of the BALB/cByJ mouse, located within 0.5 cM of chromosome 18, is responsible for reducing the mean multiplicity of urethane-induced lung tumors relative to those in C57BL/6J, A/J and C3H/HeJ mice. Thus, BALB/B6-Par2 congenic strain genetically identical to BALB/cByJ except carrying C57BL/6J Par2 alleles develops seven times more tumors than BALB/cByJ. To gain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.