Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes.

doi:10.1242/dev.127.2.291

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Article

Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes.

Development (Cambridge, England) - 1 Jan 2000

Lai E C, Bodner R, Kavaler J, Freschi G, Posakony J W

Abstract excerpt

Cell-cell signaling through the Notch receptor is a principal mechanism underlying cell fate specification in a variety of developmental processes in metazoans, such as neurogenesis. In this report we describe our investigation of seven members of a novel gene family in Drosophila with important connections to Notch signaling. These genes all encode small proteins containing predicted basic amphipathic...

Topics

3' Untranslated Regions
Amino Acid Sequence
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Lineage
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Histocytochemistry
In Situ Hybridization
Insect Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Microscopy, Electron, Scanning

Molecular Sequence Data

Nucleic Acid Hybridization

Phenotype

Protein Structure, Secondary

Source

Open in PubMed

Identifiers

PMID: 10603347
DOI: 10.1242/dev.127.2.291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.