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Article

Mixed Model Association with Family-Biased Case-Control Ascertainment.

American journal of human genetics - 5 Jan 2017

Hayeck Tristan J, Loh Po-Ru, Pollack Samuela, Gusev Alexander, Patterson Nick, Zaitlen Noah A, Price Alkes L

Abstract excerpt

Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider family-biased...

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Source

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Identifiers

PMID: 28017371
DOI: 10.1016/j.ajhg.2016.11.015
PMCID: PMC5223022

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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