Article
Role in tumorigenesis of silent mutations in the TP53 gene.
Mutation research - 20 Dec 2000
Strauss B S
Abstract excerpt
Over 10,000 mutations in the TP53 suppressor gene have been recorded in the International Agency for Research on Cancer (IARC) tumor data base. About 4% of these mutations are silent. It is a question whether these mutations play a role in tumor development. In order to approach this question, we asked whether the reported silent mutations are randomly distributed throughout the TP53 gene. The p53 data base was...
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