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Article

Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event.

Journal of hepatology - 1 Oct 1995

Kubicka S, Trautwein C, Schrem H, Tillmann H, Manns M

Abstract excerpt

BACKGROUND/AIMS: The aim of this study was to evaluate the role of p53 mutations in European hepatocarcinogenesis. METHODS: DNA extracts from 20 microdissected tumor samples were investigated. Nucleotide sequence analysis of subcloned polymerase chain reaction-fragments of the conserved domain exons 5-8 was performed in order to detect heterogeneous distribution of p53 mutated cells within the tumors. In a...

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PMID: 8655958
DOI: 10.1016/0168-8278(95)80199-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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