Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event.

doi:10.1016/0168-8278(95)80199-5

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Article

Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event.

Journal of hepatology - 1 Oct 1995

Kubicka S, Trautwein C, Schrem H, Tillmann H, Manns M

Abstract excerpt

BACKGROUND/AIMS: The aim of this study was to evaluate the role of p53 mutations in European hepatocarcinogenesis. METHODS: DNA extracts from 20 microdissected tumor samples were investigated. Nucleotide sequence analysis of subcloned polymerase chain reaction-fragments of the conserved domain ex...

Topics

Adult
Aged
Base Sequence
Carcinoma, Hepatocellular
Female
Gene Expression
Genes, p53
Humans
Immunohistochemistry
Liver Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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