Silent and multiple mutations in p53 and the question of the hypermutability of tumors.

Abstract excerpt

Published data on TP53 mutations can be used to examine the question of whether generalized hypermutability is a necessary condition for tumorigenesis. Although individual mutations do play an etiologic role in tumor formation, the evidence so far does not make it necessary to assume a general mutability. Silent and multiple mutations in the TP53 data set indicate that a special hypermutability process operates...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cells, Cultured
• Share to CHO Cells
• Share to Cricetinae