Article
Silent mutations in the gene encoding the p53 protein are preferentially located in conserved amino acid positions and splicing enhancers.
Mutation research - 30 Aug 2006
Lamolle Guillermo, Marin Mónica, Alvarez-Valin Fernando
Abstract excerpt
The last release of p53 somatic mutation database contains more than 20,000 of mutation among which 951 are silent (synonymous). This striking amount of silent mutations is much more than what would be expected if synonymous mutations were effectively neutral. The prevalent explanation to reconcile this vast amount of silent mutations with the neutral expectation is that they are just the subproduct of the...
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