Article
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Tallóczy Zsolt, Jiang Wenxia, Virgin Herbert W, Leib David A, Scheuner Donalyn, Kaufman Randal J, Eskelinen Eeva-Liisa, Levine Beth
Abstract excerpt
The eIF2alpha kinases are a family of evolutionarily conserved serine/threonine kinases that regulate stress-induced translational arrest. Here, we demonstrate that the yeast eIF2alpha kinase, GCN2, the target phosphorylation site of Gcn2p, Ser-51 of eIF2alpha, and the eIF2alpha-regulated transcriptional transactivator, GCN4, are essential for another fundamental stress response, starvation-induced autophagy. The...
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