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Article

Stress-induced gene expression requires programmed recovery from translational repression.

The EMBO journal - 3 Mar 2003

Novoa Isabel, Zhang Yuhong, Zeng Huiqing, Jungreis Rivka, Harding Heather P, Ron David

Abstract excerpt

Active repression of protein synthesis protects cells against protein malfolding during endoplasmic reticulum stress, nutrient deprivation and oxidative stress. However, long-term adaptation to these conditions requires synthesis of new stress-induced proteins. Phosphorylation of the alpha-subunit of translation initiation factor 2 (eIF2alpha) represses translation in diverse stressful conditions. GADD34 is a...

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Identifiers

PMID: 12606582
DOI: 10.1093/emboj/cdg112
PMCID: PMC150345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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