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Article

Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4).

Genome biology - 1 Jan 2000

Smirnova I, Poltorak A, Chan E K, McBride C, Beutler B

Abstract excerpt

BACKGROUND: Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that resistance to LPS is caused by defects in the Toll-like receptor 4 gene (Tlr4), the product of which is thought to bind LPS and mediate LPS signal transduction in immune system cells. RESULTS: We have sequenced the Toll-like receptor 4 gene of...

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Source

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Identifiers

PMID: 11104518
DOI: 10.1186/gb-2000-1-1-research002
PMCID: PMC31919

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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