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Article

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

10 Jul 2014

Abstract excerpt

Toll-like receptors (TLRs) belong to the pattern recognition receptor (PRR) family, a key component of the innate immune system. TLRs detect invading pathogens and initiate an immediate immune response to them, followed by a long-lasting adaptive immune response. Activation of TLRs leads to the synthesis of pro-inflammatory cytokines and chemokines and the expression of co-stimulatory molecules. TLR4 specifically...

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PMID: 25071777
DOI: 10.3389/fimmu.2014.00316

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