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Article

Variation matters: TLR structure and species-specific pathogen recognition.

Trends in immunology - 1 Mar 2009

Werling Dirk, Jann Oliver C, Offord Victoria, Glass Elizabeth J, Coffey Tracey J

Abstract excerpt

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are an important link between innate and adaptive immunity. Many vaccines incorporate ligands for TLRs as an adjuvant and are developed in rodent models, with the resulting data transferred to other species. Vaccine features can be improved markedly by emphasizing the biological relevance when evaluating other animal models for...

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Identifiers

PMID: 19211304
DOI: 10.1016/j.it.2008.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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