Article
Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.
PloS one - 1 Jan 2017
Hajjar Adeline M, Ernst Robert K, Yi Jaehun, Yam Cathy S, Miller Samuel I
Abstract excerpt
To address the role of Toll-like receptor 4 (TLR4) single nucleotide polymorphisms (SNP) in lipopolysaccharide (LPS) recognition, we generated mice that differed only in the sequence of TLR4. We used a bacterial artificial chromosome (BAC) transgenic approach and TLR4/MD-2 knockout mice to specifically examine the role of human TLR4 variants in recognition of LPS. Using in vitro and in vivo assays we found that...
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