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Article

Hereditary diffuse gastric cancer: a family diagnosis and treatment.

Clinical medicine & research - 1 Feb 2013

Onitilo Adedayo A, Aryal Govinda, Engel Jessica M

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a rare cancer representing approximately 2% of all gastric cancers. It is caused by CDHI gene mutations, inherited in an autosomal dominant fashion, that affect the function of E-cadherin. Approximately 38% of HDGC families have a CDHI gene mutation. With an estimated 75% penetrance rate, carriers are at high risk for HDGC. We describe the case of a Caucasian male of...

Topics

Adenocarcinoma
Antigens, CD
Cadherins
Gastrectomy
Genetic Predisposition to Disease
Genetic Testing
Humans
Male
Middle Aged
Mutation
Pedigree
Stomach Neoplasms

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Identifiers

PMID: 22723466
DOI: 10.3121/cmr.2012.1071
PMCID: PMC3573088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22723466-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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