Article
Novel thymidylate synthase enhancer region alleles in African populations.
Human mutation - 1 Dec 2000
Marsh S, Ameyaw M M, Githang'a J, Indalo A, Ofori-Adjei D, McLeod H L
Abstract excerpt
Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A polymorphic tandem repeat sequence in the enhancer region of the TS promoter was previously described, where the triple repeat gives higher in vitro gene expression than a double repeat. We recently identified ethnic differences in allele frequencies between Caucasian and Asian...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.