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Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.

Leukemia research - 1 Jan 2008

Giovannetti Elisa, Ugrasena Dewa G, Supriyadi Eddy, Vroling Laura, Azzarello Antonino, de Lange Desiree, Peters Godefridus J, Veerman Anjo J P, Cloos Jacqueline

Abstract excerpt

Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter (TSER), as well as in methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of TT and CT...

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Identifiers

PMID: 17395259
DOI: 10.1016/j.leukres.2007.02.011

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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