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Article

Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population.

Annals of human biology - 1 Feb 2023

Favela-Mendoza Alma Faviola, Godínez-López Andrea Dinorah, Chávez-Arreguin Mariana, Aguilar-Velázquez José Alonso, Martínez-Cortes Gabriela, Rangel-Villalobos Héctor

Abstract excerpt

BACKGROUND: In the TYMS gene promoter, there is a repeat polymorphism (TSER) that affects the expression level of the thymidylate synthetase (TS) enzyme involved in the response to some anticancer drugs. The G>C transversion located in the TSER*3R allele decreases the expression level of the TS enzyme avoiding the upstream stimulatory factor (USF-1) binding site. Despite the biomedical impact of the SNP G>C, only...

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PMID: 36789646
DOI: 10.1080/03014460.2023.2180088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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