Article
A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity.
Cancer research - 1 Jun 2003
Mandola Michael V, Stoehlmacher Jan, Muller-Weeks Susan, Cesarone Gregory, Yu Mimi C, Lenz Heinz-Josef, Ladner Robert D
Abstract excerpt
Thymidylate synthase (TS) gene expression is modulated by a polymorphism in the 5' regulatory region of the gene. The polymorphism consists mainly of either two repeats (2R) or three repeats (3R) of a 28-bp sequence, yielding greater TS gene expression and protein levels with a 3R genotype. Two USF family E-box consensus elements are found within the tandem repeats of the 3R genotype, and one is found within the...
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