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Article

Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer.

International journal of oncology - 1 Aug 2001

Marsh S, McKay J A, Cassidy J, McLeod H L

Abstract excerpt

Thymidylate synthase (TS) is an important target for chemotherapy drugs such as 5-fluorouracil and raltitrexed. Over-expression of TS has been linked to chemotherapy resistance. A polymorphic tandem repeat sequence in the 5' untranslated region (5'UTR) of the human TS gene (TSER) has been shown to influence TS expression. The presence of a triple tandem repeat (TSER*3) increases in vitro TS expression compared to...

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Share to Colorectal Neoplasms
Share to DNA, Neoplasm
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Tandem Repeat Sequences

Share to Thymidylate Synthase

Source

Identifiers

PMID: 11445856
DOI: 10.3892/ijo.19.2.383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer.PMID 11445856Read ↗

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