Article
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia.
Blood - 10 May 2012
Porcu Michaël, Kleppe Maria, Gianfelici Valentina, Geerdens Ellen, De Keersmaecker Kim, Tartaglia Marco, Foà Robin, Soulier Jean, Cauwelier Barbara, Uyttebroeck Anne, Macintyre Elizabeth, Vandenberghe Peter, Asnafi Vahid, Cools Jan
Abstract excerpt
The protein tyrosine phosphatase CD45, encoded by the PTPRC gene, is well known as a regulator of B- and T-cell receptor signaling. In addition, CD45 negatively regulates JAK family kinases downstream of cytokine receptors. Here, we report the presence of CD45 inactivating mutations in T-cell acute lymphoblastic leukemia. Loss-of-function mutations of CD45 were detected in combination with activating mutations in...
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