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Article

Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function.

Biochemistry - 23 May 2006

Tanaka Naoko, Schwer Beate

Abstract excerpt

Saccharomyces cerevisiae Prp43 is a DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome. Previous studies identified mutations in Prp43 motifs I, II, and VI that were lethal in vivo and ablated ATP hydrolysis in vitro. Such Prp43 mutants exerted dominant-negative growth phenotypes when expressed in wild type cells and blocked intron release in vitro when...

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Identifiers

PMID: 16700561
DOI: 10.1021/bi052656g
PMCID: PMC2517181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function.PMID 16700561Read ↗

Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome.Semantic proximity Read ↗

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A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Control of 3' splice site selection in S. cerevisiae by a highly conserved amino acid within the Prp8 α-finger domain.Semantic proximity Read ↗

Characterization of Cwc2, U6 snRNA, and Prp8 interactions destabilized by Prp16 ATPase at the transition between the first and second steps of splicing.Semantic proximity Read ↗

Control of 3’ Splice Site Selection in <i>S. cerevisiae</i> by a Highly Conserved Amino Acid within the Prp8 α-finger DomainSemantic proximity Read ↗

Prp43: An RNA helicase-like factor involved in spliceosome disassembly.Semantic proximity Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis.Semantic proximity Read ↗

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