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Article

Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor.

The Journal of biological chemistry - 16 Feb 2001

Wu Z, Simister N E

Abstract excerpt

The neonatal Fc receptor, FcRn, transports immunoglobulin G across intestinal cells in suckling rats. FcRn enters these cells by endocytosis and is present on the apical and basolateral surfaces. We investigated the roles of aromatic amino acids and a dileucine motif in the cytoplasmic domain of rat FcRn. We expressed mutant FcRn in which alanine replaced Trp-311, Leu-322, and Leu-323, or Phe-340 in the inner...

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Identifiers

PMID: 11096078
DOI: 10.1074/jbc.M006684200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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