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Article

Dependence of antibody-mediated presentation of antigen on FcRn.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008

Qiao Shuo-Wang, Kobayashi Kanna, Johansen Finn-Eirik, Sollid Ludvig M, Andersen Jan Terje, Milford Edgar, Roopenian Derry C, Lencer Wayne I, Blumberg Richard S

Abstract excerpt

The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen...

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Share to Antigen-Antibody Complex
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18599440
DOI: 10.1073/pnas.0801717105
PMCID: PMC2453734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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