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Article

Structural insights into neonatal Fc receptor-based recycling mechanisms.

The Journal of biological chemistry - 14 Mar 2014

Oganesyan Vaheh, Damschroder Melissa M, Cook Kimberly E, Li Qing, Gao Changshou, Wu Herren, Dall'Acqua William F

Abstract excerpt

We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands. More particularly, we solved the crystal structure of the complex between human FcRn, wild-type human serum albumin (HSA), and a human Fc engineered for improved pharmacokinetics properties (Fc-YTE). The crystal structure of human FcRn bound to wild-type HSA alone is also presented. HSA...

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Share to Crystallization
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Bonding

Share to Hydrogen-Ion Concentration

Share to Immunoglobulin Fc Fragments

Share to Immunoglobulin G

Share to Receptors, Fc

Share to Serum Albumin

Source

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Identifiers

PMID: 24469444
DOI: 10.1074/jbc.M113.537563
PMCID: PMC3953293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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