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Article

Nucleotide-sequence-specific and non-specific interactions of T4 DNA polymerase with its own mRNA.

Nucleic acids research - 1 Dec 2000

Pavlov A R, Karam J D

Abstract excerpt

The DNA-binding DNA polymerase (gp43) of phage T4 is also an RNA-binding protein that represses translation of its own mRNA. Previous studies implicated two segments of the untranslated 5'-leader of the mRNA in repressor binding, an RNA hairpin structure and the adjacent RNA to the 3' side, which contains the Shine-Dalgarno sequence. Here, we show by in vitro gp43-RNA binding assays that both translated and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11095675
DOI: 10.1093/nar/28.23.4657
PMCID: PMC115167

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Source receipt: pubmed, retrieved 7 Sept 2026.

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