Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.

Nucleic acids research - 15 Mar 2000

Lin X, Parsels L A, Voeller D M, Allegra C J, Maley G F, Maley F, Chu E

Abstract excerpt

Thymidylate synthase (TS) functions as an RNA-binding protein by interacting with two different sequences on its own mRNA. One site is located in the 5'-upstream region of human TS mRNA while the second site is located within the protein coding region corresponding to nt 434-634. In this paper, a 70 nt RNA sequence, corresponding to nt 480-550, was identified that binds TS protein with an affinity similar to that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Fluorouracil
Share to Inhibitory Concentration 50

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Open Reading Frames

Share to Precipitin Tests

Share to Protein Biosynthesis

Share to Response Elements

Share to Thymidylate Synthase

Source

Open in PubMed Open full text

Identifiers

PMID: 10684933
DOI: 10.1093/nar/28.6.1381
PMCID: PMC111044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.PMID 10684933Read ↗

Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.Semantic proximity Read ↗

In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase.Semantic proximity Read ↗

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancerSemantic proximity Read ↗

Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase.Semantic proximity Read ↗

Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.Semantic proximity Read ↗

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression.Semantic proximity Read ↗

Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.Semantic proximity Read ↗

Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein ComplexSemantic proximity Read ↗

Regulation of p53 expression by thymidylate synthaseSemantic proximity Read ↗

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levelsSemantic proximity Read ↗

Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene.Semantic proximity Read ↗

The presence of three repeats in the 5' UTR region of thymidylate synthase (TS) is associated with increased TS mRNA expression in cultured human cancer cell lines in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.