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Article

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

1 Jan 2001

Abstract excerpt

The Flt3 gene encodes a tyrosine kinase receptor that regulates proliferation and differentiation of hematopoietic stem cells. An internal tandem duplication of the Flt3 gene (Flt3/ITD) has been reported in acute myelogenous leukemia (AML) and may be associated with poor prognosis. We analyzed diagnostic bone marrow specimens from 91 pediatric patients with AML treated on Children's Cancer Group (CCG)-2891 for...

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PMID: 11133746
DOI: 10.1182/blood.v97.1.89

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