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Article

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.

Journal of neurochemistry - 1 Dec 2000

Ko L, Mehta N D, Farrer M, Easson C, Hussey J, Yen S, Hardy J, Yen S H

Abstract excerpt

Linkage of alpha-synuclein (alpha-SN) mutations to familial Parkinson's disease (PD) and presence of alpha-SN as a major constituent of Lewy body in both sporadic and familial PD implicate alpha-SN abnormality in PD pathogenesis. Here we demonstrate that overexpression of wild-type or mutant alpha-SN does not cause any deleterious effect on the growth or continued propagation of transfected human cells, but...

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Identifiers

PMID: 11080208
DOI: 10.1046/j.1471-4159.2000.0752546.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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