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Article

Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.

Current protein & peptide science - 1 Oct 2009

McCormack Alison L, Di Monte Donato A

Abstract excerpt

When caused by multiplication mutations of its gene, increased expression of alpha-synuclein is associated with familial parkinsonism. Here we discuss the possibility that other mechanisms of alpha-synuclein elevation contribute to the pathogenesis of idiopathic, sporadic Parkinson's disease and other human synucleinopathies. Environmental (e.g. toxic exposures) and genetic (e.g. gene polymorphisms) risk factors,...

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Identifiers

PMID: 19538156
DOI: 10.2174/138920309789351912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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