Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma.

doi:10.1038/sj.onc.1203903

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Article

Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma.

Oncogene - 2 Nov 2000

Yeh C T, Shen C H, Tai D I, Chu C M, Liaw Y F

Abstract excerpt

The aim of this study was to investigate whether there was a particular hepatitis B virus (HBV) X protein (HBx) mutant associated with Taiwanese patients with hepatocellular carcinoma (HCC). Initially, the entire coding region of HBx gene from the serum samples of 14 Taiwanese patients were sequenced. A novel mutant, HBx-A31, was preferentially found in patients with HCC. Sera from 67 patients with HCC and 100...

Topics

Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Carcinoma, Hepatocellular
Caspase 1
Caspase 3
Caspases
Codon
DNA Mutational Analysis
Enhancer Elements, Genetic
Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Viral

Gene Frequency

Genome, Viral

Hepatitis B virus

Hepatitis B, Chronic

Humans

Liver Cirrhosis

Source

Open in PubMed

Identifiers

PMID: 11077437
DOI: 10.1038/sj.onc.1203903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11077437-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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