Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of HBx Mutations in Chronic Hepatitis B with Acute Exacerbation.

Viruses - 7 Sept 2025

Chen Xiaobei, Shi Jinzhi, Zhou Ping, Tian Yunyun, Zheng Yajing, Liu Tingting, Li Yan, Zhu Fan

Abstract excerpt

Hepatitis B virus (HBV) infection remains a significant global health burden, primarily due to its chronic complications, including acute exacerbation, cirrhosis, hepatocellular carcinoma (HCC), and related sequelae. Acute exacerbation of chronic hepatitis B (CHB-AE) is common and often represents the earliest clinical manifestation. The Hepatitis B virus X protein (HBx) (17-kDa) is not only essential for viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Disease Progression
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Trans-Activators

Share to Viral Regulatory and Accessory Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 41012651
DOI: 10.3390/v17091223
PMCID: PMC12474432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of HBx Mutations in Chronic Hepatitis B with Acute Exacerbation.PMID 41012651Read ↗

X region mutations of hepatitis B virus related to clinical severity.Semantic proximity Read ↗

The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.Semantic proximity Read ↗

Evolutionary and functional landscape of HBx mutations in genotype D1 HBV: comparative insights from acute infection, chronic hepatitis, and HCCSemantic proximity Read ↗

The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updatesSemantic proximity Read ↗

Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive ReviewSemantic proximity Read ↗

Comparison of hepatitis B X gene mutation between patients with hepatocellular carcinoma and patients with chronic hepatitis B.Semantic proximity Read ↗

Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma.Semantic proximity Read ↗

Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.Semantic proximity Read ↗

Hepatitis B viral factors and clinical outcomes of chronic hepatitis B.Semantic proximity Read ↗

Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinomaSemantic proximity Read ↗

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China.Semantic proximity Read ↗

The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.