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Article

Polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer risk.

International journal of oncology - 1 Nov 2004

Singal Rakesh, Ferdinand Larry, Das Partha M, Reis Isildinha M, Schlesselman James J

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. Genetic polymorphisms that decrease MTHFR activity result in an altered cancer risk depending on folic acid intake. In this study we examined the C677T and A1298C polymorphisms of the MTHFR gene in specimens from 81 patients with prostate cancer and...

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Source

Identifiers

PMID: 15492840

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the methylenetetrahydrofolate reductase gene and prostate cancer risk.PMID 15492840Read ↗

Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study.Semantic proximity Read ↗

MTHFR polymorphism and the risk of prostate cancer: a meta-analysis of case-control studies.Semantic proximity Read ↗

Analysis of relation between C677T genotype in MTHFR gene and prostatic cancer in Iranian males.Semantic proximity Read ↗

MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: A meta-analysis of 3511 cases and 2762 controls.Semantic proximity Read ↗

Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis.Semantic proximity Read ↗

Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer.Semantic proximity Read ↗

Association between MTHFR C677T Polymorphism and Risk of Prostate Cancer: Evidence from 22 Studies with 10,832 Cases and 11,993 Controls.Semantic proximity Read ↗

The MTHFR C677T polymorphism and prostate cancer risk: new findings from a meta-analysis of 7306 cases and 8062 controls.Semantic proximity Read ↗

Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan.Semantic proximity Read ↗

MTHFR c.677C>T Inhibits Cell Proliferation and Decreases Prostate Cancer Susceptibility in the Han Chinese Population in Shanghai.Semantic proximity Read ↗

The Analysis of the Relationship Between A1298C and C677T Polymorphisms of the <i>MTHFR</i> Gene with Prostate Cancer in Eskisehir PopulationSemantic proximity Read ↗

The protective effect of methylenetetrahydrofolate reductase C677T polymorphism against prostate cancer risk: Evidence from 23 case-control studies.Semantic proximity Read ↗

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