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Article

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study.

Clinical biochemistry - 1 Sept 2007

Reljic Ante, Simundic Ana-Maria, Topic Elizabeta, Nikolac Nora, Justinic Danijel, Stefanovic Mario

Abstract excerpt

OBJECTIVES: Methylation abnormalities appear to be important for the pathogenesis of many cancer types. Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methylation process catalyzing reduction of 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, C677T polymorphism, which decreases enzyme activity, may be associated with cancer susceptibility. The aim of this work was to...

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Source

Identifiers

PMID: 17573062
DOI: 10.1016/j.clinbiochem.2007.05.005

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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