Article
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study.
Clinical biochemistry - 1 Sept 2007
Reljic Ante, Simundic Ana-Maria, Topic Elizabeta, Nikolac Nora, Justinic Danijel, Stefanovic Mario
Abstract excerpt
OBJECTIVES: Methylation abnormalities appear to be important for the pathogenesis of many cancer types. Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methylation process catalyzing reduction of 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, C677T polymorph...
Topics
- Aged
- Breast Neoplasms
- Case-Control Studies
- Croatia
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Head and Neck Neoplasms
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Neoplasms
- Polymorphism, Single Nucleotide
- Prostatic Neoplasms
- Risk Factors