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Article

Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells.

International journal of cancer - 1 Sept 2001

Pajic A, Staege M S, Dudziak D, Schuhmacher M, Spitkovsky D, Eissner G, Brielmeier M, Polack A, Bornkamm G W

Abstract excerpt

Epstein-Barr virus (EBV) immortalized cells and Burkitt lymphoma cells have a completely different growth pattern and phenotype. EBV immortalized cells express a set of 11 viral genes to accommodate B cell activation and proliferation, whereas EBV-positive Burkitt lymphoma cells highly express the c-myc oncogene that is activated through translocation into 1 of the immunoglobulin loci and EBNA1 as the only viral...

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Source

Identifiers

PMID: 11519042
DOI: 10.1002/ijc.1404

Genes

MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells.PMID 11519042Read ↗

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c-Myc and Rel/NF-κB Are the Two Master Transcriptional Systems Activated in the Latency III Program of Epstein-Barr Virus-Immortalized B CellsSemantic proximity Read ↗

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MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells.Semantic proximity Read ↗

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