Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c‐MYC activation impairs the NF‐κB and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma

8 Jan 2007

Abstract excerpt

Deregulation of the proto-oncogene c-myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c-myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a restricted set of Epstein-Barr viral (EBV) antigens, BL cells are not recognized by antigen-specific cytotoxic T cells (CTLs) because of their inability to process and present HLA class...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphoma Diagnosis and Treatment
Share to T-cell and Retrovirus Studies
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17211884
DOI: 10.1002/ijc.22372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c‐MYC activation impairs the NF‐κB and the interferon response: Implications for the pathogenesis of Burkitt's lymphomaPMID 17211884Read ↗

The IKK2/NF-κB pathway suppresses MYC-induced lymphomagenesisSemantic proximity Read ↗

c-Myc and Rel/NF-κB Are the Two Master Transcriptional Systems Activated in the Latency III Program of Epstein-Barr Virus-Immortalized B CellsSemantic proximity Read ↗

Role of NFAT in Chronic Lymphocytic Leukemia and Other B-Cell MalignanciesSemantic proximity Read ↗

MYC Functions as a Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid MalignanciesSemantic proximity Read ↗

Elevation of c-MYC Disrupts HLA Class II–Mediated Immune Recognition of Human B Cell TumorsSemantic proximity Read ↗

Epstein-Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2.Semantic proximity Read ↗

MYC promotes immune-suppression in TNBC via inhibition of IFN signalingSemantic proximity Read ↗

NOTCH1 drives immune-escape mechanisms in B cell malignanciesSemantic proximity Read ↗

Burkitt Lymphoma: Revisiting the Pathogenesis of a Virus-Associated MalignancySemantic proximity Read ↗

MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells.Semantic proximity Read ↗

Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in miceSemantic proximity Read ↗

Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escapeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.