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Article

STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008

Diehl Sean A, Schmidlin Heike, Nagasawa Maho, van Haren Simon D, Kwakkenbos Mark J, Yasuda Etsuko, Beaumont Tim, Scheeren Ferenc A, Spits Hergen

Abstract excerpt

STAT family members have been implicated in regulating the balance between B cell lymphoma (BCL)6 and B lymphocyte induced maturation protein (BLIMP)1 to control plasma cell differentiation. We previously showed that STAT5 induces BCL6 to block plasma cell differentiation and extend the life span of human B cells. The heterogeneity in STAT activation by cytokines and their effects on B cell differentiation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18354204
DOI: 10.4049/jimmunol.180.7.4805
PMCID: PMC2396731

Genes

STAT3
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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