Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of interleukin-1 receptor antagonist gene polymorphism on disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2002

Witkin Steven S, Gerber Stefan, Ledger William J

Abstract excerpt

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring competitive inhibitor of interleukin-1 (IL-1)-induced proinflammatory activity. The IL-1RA gene is polymorphic, resulting in quantitative differences in both IL-1RA and IL-1beta production. Persons homozygous for allele 2 of the IL-1RA gene (IL1RN*2) have a more prolonged and more severe proinflammatory immune response than persons with other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Interleukin 1 Receptor Antagonist Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Receptors, Interleukin-1

Share to Sialoglycoproteins

Source

Identifiers

PMID: 11740709
DOI: 10.1086/338261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of interleukin-1 receptor antagonist gene polymorphism on disease.PMID 11740709Read ↗

IL-1 receptor antagonist gene polymorphism in recurrent spontaneous abortion.Semantic proximity Read ↗

IL-1 receptor antagonist (IL-1Ra) gene polymorphism in patients with inflammatory bowel disease in India.Semantic proximity Read ↗

Interleukin-1 receptor antagonist gene polymorphism in epithelial ovarian cancer.Semantic proximity Read ↗

Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis.Semantic proximity Read ↗

Polymorphism of IL-1 receptor antagonist gene: role in cancer.Semantic proximity Read ↗

Association of Intron-2 Variable Numbers of an 86-bp Tandem Repeat-Polymorphisms of Interleukin-1 Receptor Antagonist Gene and Idiopathic Recurrent Spontaneous Abortion.Semantic proximity Read ↗

Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis.Semantic proximity Read ↗

Interleukin-1 receptor antagonist gene polymorphism and susceptibility to ischemic stroke.Semantic proximity Read ↗

Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.Semantic proximity Read ↗

Interleukin 1 receptor antagonist polymorphism in women with idiopathic recurrent miscarriage.Semantic proximity Read ↗

Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1beta and interleukin-1 receptor antagonist and pregnancy outcome.Semantic proximity Read ↗

Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.