Article
Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis.
Stroke - 1 Mar 2003
Worrall Bradford B, Azhar Salman, Nyquist Paul A, Ackerman Robert H, Hamm Theresa L, DeGraba Thomas J
Abstract excerpt
BACKGROUND AND PURPOSE: Inflammation plays an important role in the development of atherosclerosis. The gene for the counterinflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) is polymorphic, and high frequencies of allele 2 have been found to be associated with other inflammatory diseases. This study examined the association of allele and carrier frequencies of the IL-1ra gene with the presence of...
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