Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist.

European journal of immunology - 1 Oct 2002

Vamvakopoulos Joannis, Green Colin, Metcalfe Su

Abstract excerpt

Regulation of IL-1 bioactivity by the IL-1 receptor antagonist (IL-1Ra) is critical for the preservation of normal vascular structure and function in mice. In humans, IL-1 bioactivity may be further fine-tuned by genetic polymorphisms. We recently proposed that an intronic polymorphism of the human gene encoding the IL-1R antagonist (IL1RN) is a genetic risk factor for the development of chronic cardiac allograft...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Graft Rejection
Share to Heart Transplantation
Share to Interleukin-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin 1 Receptor Antagonist Protein

Share to Lipopolysaccharides

Share to Protein Isoforms

Share to Sialoglycoproteins

Share to Transplantation, Homologous

Source

Identifiers

PMID: 12355453
DOI: 10.1002/1521-4141(2002010)32:10<2988::AID-IMMU2988>3.0.CO;2-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist.PMID 12355453Read ↗

Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes.Semantic proximity Read ↗

Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals.Semantic proximity Read ↗

Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.Semantic proximity Read ↗

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.Semantic proximity Read ↗

Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1β in idiopathic pulmonary fibrosis.Semantic proximity Read ↗

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.Semantic proximity Read ↗

IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes.Semantic proximity Read ↗

Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1beta production in vitro.Semantic proximity Read ↗

[Genetic polymorphisms related to interleukin-1 beta production and disease risk].Semantic proximity Read ↗

Interleukin 1 gene polymorphism and susceptibility to disease.Semantic proximity Read ↗

Interleukin 1 and chronic rejection: possible genetic links in human heart allografts.Semantic proximity Read ↗

Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.