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Article

Interleukin-1 receptor antagonist (IL-1RN) genotype modulates the replicative capacity of human endothelial cells.

Circulation research - 27 Jun 2003

Dewberry Rachael M, Crossman David C, Francis Sheila E

Abstract excerpt

Endothelial cells (ECs) undergo a finite number of cell divisions before growth arrest or replicative senescence, modulated in part by the proinflammatory cytokine, interleukin-1 (IL-1). IL-1 and its family members are expressed in human atherosclerotic vessels, mainly in the endothelium. EC replicative senescence and IL-1 have been associated with atherosclerosis. Genetic variants at the IL-1 locus have been...

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Identifiers

PMID: 12764021
DOI: 10.1161/01.RES.0000078172.52740.9B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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