Article
Genetic analysis of immunomodulating factors in sporadic Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2000
Krüger R, Hardt C, Tschentscher F, Jäckel S, Kuhn W, Müller T, Werner J, Woitalla D, Berg D, Kühnl N, Fuchs G A, Santos E J, Przuntek H, Epplen J T, Schöls L, Riess O
Abstract excerpt
Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFalpha) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFalpha, and the TNFalpha receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age...
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