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Article

Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish.

Human immunology - 1 Apr 2004

Ross Owen A, O'Neill Claire, Rea I Maeve, Lynch Tim, Gosal David, Wallace Andrew, Curran Martin D, Middleton Derek, Gibson J Mark

Abstract excerpt

Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders and is characterized by the progressive loss of dopamine neurons in the substantia nigra. There is increasing evidence to suggest the inflammatory response of the brain contributes to the pathogenesis of PD. This study investigated the frequency of polymorphism located in the critical promoter region of the proinflammatory cytokine...

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Source

Identifiers

PMID: 15120188
DOI: 10.1016/j.humimm.2004.01.015

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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