Article
Interleukin-1 alpha polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2007
Wu Y R, Chen C M, Hwang J C, Chen S T, Feng I H, Hsu H C, Liu C N, Liu Y T, Lai Y Y, Huang H J, Lee-Chen G J
Abstract excerpt
Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1alpha C-889T and IL-1beta C-511T polymorphisms with the risk of PD. No significant difference in the genotype...
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