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Article

TNF-α -308 G/A and -238 G/A promoter polymorphisms and sporadic Parkinson's disease in an Italian cohort.

Journal of the neurological sciences - 15 Feb 2018

Agliardi Cristina, Guerini Franca Rosa, Zanzottera Milena, Riboldazzi Giulio, Zangaglia Roberta, Bono Giorgio, Casali Carlo, Di Lorenzo Cherubino, Pacchetti Claudio, Nemni Raffaello, Clerici Mario

Abstract excerpt

The etiology of sporadic Parkinson's disease is (PD) still not understood but it is believed that a complex interplay between environmental and genetic factors could trigger the pathology. Pro-inflammatory TNF-α is released by activated microglia and is up-regulated in the brain and cerebrospinal fluid of PD patients; TNF-α modulates neuroinflammation and can activate the molecular mechanisms that lead to...

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Source

Identifiers

PMID: 29406912
DOI: 10.1016/j.jns.2017.12.011

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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