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Article

DNA-triplex stabilizing properties of 8-aminoguanine.

Nucleic acids research - 15 Nov 2000

Soliva R, Güimil García R, Blas J R, Eritja R, Asensio J L, González C, Luque F J, Orozco M

Abstract excerpt

A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calculations, and demonstrated by melting experiments. NMR experiments confirm the triplex-stabilizing properties of 8-aminoguanine and...

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Identifiers

PMID: 11071942
DOI: 10.1093/nar/28.22.4531
PMCID: PMC113881

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