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Article

Strong binding of naphthyridine derivatives to a guanine base in DNA duplexes containing an AP site.

Nucleic acids symposium series (2004) - 1 Jan 2005

Gao Qiang, Satake Hiroyuki, Dai Qing, Ono Katsuya, Nishizawa Seiichi, Teramae Norio

Abstract excerpt

By using UV thermal denaturation and isothermal titration calorimetry (ITC), we examine the binding behaviors of a hydrogen bond-forming ligand, 2-acetylamino-7-methyl-1,8-naphthyridine (AcMND), with a guanine base opposite an abasic site (AP site) in a DNA duplex (5'-TCC AGX GCA AC-3'/3'-AGG TCG CGT TG-5', X = AP site, G = target). In the presence of AcMND, the melting temperature (Tm) of the AP site-containing...

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PMID: 17150712
DOI: 10.1093/nass/49.1.219

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GCA

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