Article
An environmentally sensitive fluorescent purine nucleoside that changes emission wavelength upon hybridization.
Chemical communications (Cambridge, England) - 25 Jun 2013
Saito Yoshio, Suzuki Azusa, Okada Yuji, Yamasaka Yuki, Nemoto Nobukatsu, Saito Isao
Abstract excerpt
C7-naphthylethynylated 8-aza-7-deaza-2'-deoxyguanosine (na)G was synthesized and its photophysical properties were examined. The fluorescent nucleoside exhibited solvatofluorochromic properties (Δλ(fl)(max) = 67 nm). An ODN probe containing (na)G forms a stable base pair only with C and discriminates structural changes such as mismatches and deletions by a distinct change in its emission wavelength.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.