Article
Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015
Peng Chunte Sam, Fedeles Bogdan I, Singh Vipender, Li Deyu, Amariuta Tiffany, Essigmann John M, Tokmakoff Andrei
Abstract excerpt
Antiviral drugs designed to accelerate viral mutation rates can drive a viral population to extinction in a process called lethal mutagenesis. One such molecule is 5,6-dihydro-5-aza-2'-deoxycytidine (KP1212), a selective mutagen that induces A-to-G and G-to-A mutations in the genome of replicating HIV. The mutagenic property of KP1212 was hypothesized to originate from its amino-imino tautomerism, which would...
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