Article
An intricate balance of hydrogen bonding, ion atmosphere and dynamics facilitates a seamless uracil to cytosine substitution in the U-turn of the neomycin-sensing riboswitch.
Nucleic acids research - 27 Jul 2018
Krepl Miroslav, Vögele Jennifer, Kruse Holger, Duchardt-Ferner Elke, Wöhnert Jens, Sponer Jiri
Abstract excerpt
The neomycin sensing riboswitch is the smallest biologically functional RNA riboswitch, forming a hairpin capped with a U-turn loop-a well-known RNA motif containing a conserved uracil. It was shown previously that a U→C substitution of the eponymous conserved uracil does not alter the riboswitch structure due to C protonation at N3. Furthermore, cytosine is evolutionary permitted to replace uracil in other...
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