Article
Thermodynamic characterization of the binding of naphthyridines to the AP site-containing DNA duplexes.
Nucleic acids symposium series (2004) - 1 Jan 2006
Sato Yusuke, Seino Takehiro, Nishizawa Seiichi, Teramae Norio
Abstract excerpt
We here report on the thermodynamics of the hydrogen bond-mediated binding of 2-amino-7-methyl-1,8-naphthyridine (AMND) to a cytosine base opposite an abasic site (AP site) in a 21-meric DNA duplex (5'-GCA GCT CCC GXG GTC TCC TCG-3'/3'-CGT CGA GGG CCC CAG AGG AGC-5', X= AP site, C = target). The...
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